© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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FR-targeted DNA crosslinking agent conjugate
activity in xenograft w/ once weekly dosing
from conjugation of FR-ligand and PBD dimer
Sci. Rep., Jul. 29, 2020
Endocyte, West Lafayette, IN / Novartis
EC2629 is a folate receptor (FR)-targeted small molecule drug conjugate with a folate receptor-targeting moiety, a pyrrolobenzodiazepine (PBD) DNA-crosslinking warhead, and a linker. Similar to antibody-drug conjugates, this small molecule…
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