FR-targeted DNA crosslinking agent conjugate

activity in xenograft w/ once weekly dosing

from conjugation of FR-ligand and PBD dimer

Sci. Rep., Jul. 29, 2020

Endocyte, West Lafayette, IN / Novartis

Structure of EC2629, a folate receptor (FR)-targeted small molecule drug conjugate

EC2629 is a folate receptor (FR)-targeted small molecule drug conjugate with a folate receptor-targeting moiety, a pyrrolobenzodiazepine (PBD) DNA-crosslinking warhead, and a linker. Similar to antibody-drug conjugates, this small molecule…


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