oral prodrug of serine _-lactamase inh.

in dev. for multidrug resistant bact. infection

from optimization of prior _-lactamase inh.

J. Med. Chem., Jul. 24, 2020

Entasis Therapeutics, Waltham, MA

ETX0282 is an oral prodrug of a class A, C, and D serine β-lactamase inhibitor in clinical development for drug-resistant enterobacterial infections in combination with the beta-lactam drug cefpodoxime proxetil.…


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