potent, bioavailable autotaxin inhibitor

orally active in fibrosis mod., Ph. I IND cleared

from 225M cmpd DNA-encoded library + opt.

J. Med. Chem., Jul. 23, 2020

X-Chem, Waltham, MA

Structure of X-165, a highly potent and selective small molecule inhibitor of Autotaxin

X-165 is an autotaxin inhibitor clinical candidate for idiopathic pulmonary fibrosis discovered using a 3-cycle DEL screen of 225M compounds derived from amide couplings. An unusual spirocyclic amine building block…

get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: