Structure of CGRP receptor agonist HTL22562

potent, non-oral CGRP antagonist

clean profile in 10-day rodent tox.

from SBDD of prior ligand

J. Med. Chem., Jul. 23, 2020

Sosei Heptares, Cambridge, UK

HTL22562 is a CGRP antagonist intended to treat acute migraines. Some prior oral CGRP antagonists failed in clinical trials due to liver tox. signals, so this program targeted a non-oral…

 this content is exclusive to
Premium members

Unlock this content with a Premium membership to read it now.