kinetoplastid-selective proteasome inhibitor

oral antileishmanial in Ph. I in HV

From 3M cmpd antiprolif. screen + opt.

J. Med. Chem., Jul. 29, 2020

Novartis (GNF), San Diego, CA

Structure of LXE408

LXE408 is an oral antileishmanarial compound that selectively targets the kinetoplastid proteosome vs. the mammalian proteosome. The prior candidate, GNF6702, had solubility-limited oral absorption, which could have been addressed with…

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