Structure of compound 18

orally available fetal hemoglobin inducer

oral induction of fetal hemoglobal in cyno

from phenotypic screen and ADME opt.

Bioorg. Med. Chem. Lett., Jul. 24, 2020

Daiichi-Sankyo, Tokyo, JP / Asubio

“compound 18” is an oral inducer of fetal hemoglobin (HbF) intended to treat anemias such as sickle cell disease and beta-thalassemia. The authors identified a weak hit (>10 uM) from…

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