© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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potent, selective, Q2W IV CD73 inhibitor
completed Ph. I in HV, in dev. for cancer imm.
from opt. of known nucleotide CD73 inh.
J. Med. Chem., Jul. 20, 2020
Arcus Biosciences, Hayward, CA
AB680 is a potent (5 pM) and selective inhibitor of CD73, a nucleotidase that metabolizes AMP to immunosuppressive extracellular adenosine. AB680 is intended to be used in combination with checkpoint…
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