Structure of AB680, a potent small-molecule inhibitor of CD73

potent, selective, Q2W IV CD73 inhibitor

completed Ph. I in HV, in dev. for cancer imm.

from opt. of known nucleotide CD73 inh.

J. Med. Chem., Jul. 20, 2020

Arcus Biosciences, Hayward, CA

AB680 is a potent (5 pM) and selective inhibitor of CD73, a nucleotidase that metabolizes AMP to immunosuppressive extracellular adenosine. AB680 is intended to be used in combination with checkpoint…

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