Small Molecules of the Month – Jan. 2021

For the first installment of Drug Hunter’s “Small Molecules of the Month” series in 2021, we have a Kissei SGLT2 inhibitor whose lead was a metabolite found in mouse urine, a GSK integrin inhibitor that was found to trigger lysosomal …

2020 Small Molecules of the Year

In 2020 the Drug Hunter site highlighted >150 “molecules of the month” whose structures or stories were typically published for the first time. They were selected from thousands of research articles, published by leading institutions around the world. It was …

The Square-Cube Law in Chemistry and Biology

Assume a cow is an evenly distributed sphere… sometimes. I happened to take an animal physiology course in college because my girlfriend (now wife) needed it for her biology major and taking a class together about bird metabolism was my …

Small Molecules of the Month – Nov. 2020

Hope everyone had a fantastic Christmas weekend. Last month there were quite a few large small molecules, including three macrocycles. Quite a few of these molecules would’ve made for a decent synthesis PhD project! Some highlights include a cryo-EM structure …