For the first installment of Drug Hunter’s “Small Molecules of the Month” series in 2021, we have a Kissei SGLT2 inhibitor whose lead was a metabolite found in mouse urine, a GSK integrin inhibitor that was found to trigger lysosomal …
On Feb. 16, 12:00PM PST, I’ll be hosting Dr. Mira Pochon, Staff Scientist and Head of Translational Biology at Global Blood Therapeutics, for a PBSS/CLSA webinar on one of my favorite 2019 drug approvals, voxelotor (GBT440). Mira has been with …
In 2020 the Drug Hunter site highlighted >150 “molecules of the month” whose structures or stories were typically published for the first time. They were selected from thousands of research articles, published by leading institutions around the world. It was …
Assume a cow is an evenly distributed sphere… sometimes. I happened to take an animal physiology course in college because my girlfriend (now wife) needed it for her biology major and taking a class together about bird metabolism was my …
Happy 2021! Here’s the last installment of Small Molecules of the Month for 2020. It was so hard to narrow this down to one sheet of molecules since there were so many timely publications in December. One of my favorites …
Hope everyone had a fantastic Christmas weekend. Last month there were quite a few large small molecules, including three macrocycles. Quite a few of these molecules would’ve made for a decent synthesis PhD project! Some highlights include a cryo-EM structure …