Structure of compound 38a

orally active ChemR23 GPCR inhibitor

oral effects on dendritic cells in higher species

from cell-based screen and optimization

Bioorg. Med. Chem., Jul. 14, 2020

Kyowa Kirin, Shizuoka, JP

“compound 38a” is an inhibitor of ChemR23, a chemokine-receptor-like GPCR with a role in plasmacytoid dendritic cell (pDC) trafficking. The ChemR23 inhibitor was developed with the intention of suppressing the…

 this content is exclusive to
Premium members

Unlock this content with a Premium membership to read it now.