orally active ChemR23 GPCR inhibitor

oral effects on dendritic cells in higher species

from cell-based screen and optimization

Bioorg. Med. Chem., Jul. 14, 2020

Kyowa Kirin, Shizuoka, JP

“compound 38a” is an inhibitor of ChemR23, a chemokine-receptor-like GPCR with a role in plasmacytoid dendritic cell (pDC) trafficking. The ChemR23 inhibitor was developed with the intention of suppressing the…


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