The drug discovery community kicked off the summer with a lot of very interesting molecules published in June. After ~50 molecular highlights so far this year, you’d think we’ve seen it all, but there were again numerous fascinating chemical motifs, molecular mechanisms, and biological observations disclosed last month. In this group are some natural-product inspired molecules, two metal-binding molecules (including a drug that binds its target via its ketone hydrate, something I had not seen before!), two transcription factor modulators, a molecular glue degrader, a receptor tetramerizer, and several clinical candidates. Links to the articles and more commentary below.