Hope everyone had a fantastic Christmas weekend. Last month there were quite a few large small molecules, including three macrocycles. Quite a few of these molecules would’ve made for a decent synthesis PhD project! Some highlights include a cryo-EM structure for Chugai/Lilly’s GLP-1R agonist, a Ra Pharma mRNA display screen yielding a PCSK9 PPI inhibitor, and a crystal structure of a BTK-degrader-cIAP ternary complex from Pfizer. Enjoy!
Molecules of the Month
November 2020
- LY3502970
- S64315
- daridorexant
- "peptide 78"
- BMS-986144
- MLT-985
- EB-42486
- "compound 4d"
- "compound 60b"
- "compound 15a"
- "compound 31"
- "compound 36"
- BCPyr
- "compound 4j"
Molecules of the Month
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