This section contains case studies, industry highlights, minireviews, and other articles for drug discovery professionals. Check out the resources page for posters, educational content, lists of drug approvals, and more.
Macrocyclic molecules, containing 12 or more atoms in a ring system, are increasingly prevalent in drug discovery, with over 67…
Article
1 day ago ●
8 mins read
“I was told early on that developing an oral PCSK9 inhibitor is impossible.” The Merck macrocyclic PCSK9 protein-protein interaction (PPI)…
molecule
2 days ago ●
13 mins read
The first non-ATP-competitive inhibitor of the long-pursued PI3Kδ kinase. Phosphatidylinositol-3-kinase (PI3K) has received intense attention as a drug target from…
molecule
3 days ago ●
8 mins read
This article compiles 20+ recent small molecules of general interest in the news in April 2023, with structures where they…
Article
6 days ago ●
12 mins read
A potential first-in-class oral antibiotic with recent positive Ph. III data. The orally administered gepotidacin is a member of a…
molecule
7 days ago ●
5 mins read
Potential for an improved sGC stimulator for resistant hypertension. BAY 1165747 (BAY-747) is a new, structurally distinct, soluble guanylate cyclase…
molecule
1 week ago ●
5 mins read
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