fbpx

molecules of the month

MGS0274

oral prodrug of mGlu2/3 receptor agonist

in development for schizophrenia

from derivatization of active molecule

Eur. J. Med. Chem., Jul. 5, 2020

Taisho Pharmaceutical, Saitama, JP

Structure of MGS0274, a potent and selective agonist of mGlu2 and mGlu3 receptors
1 min read

MGS0274 is a prodrug of an mGlu2/3 receptor agonist with ca. 15x greater oral exposure than the parent. The ester is believed to be cleaved pre-systemically by liver carboxyesterases to release the innocuous byproducts acetaldehyde, CO2, and menthol. The parent is also an interesting looking molecule prepared in a few steps from cyclopentenone (ref. 9 in article).


request a trial

Drug Hunter is commited to helping industry innovators make informed decisions. Premium members have access to our library of the latest stories in science, written by scientists.

Request a trial to access insights powering the pros in our industry.


already a member? log in: