oral prodrug of mGlu2/3 receptor agonist
in development for schizophrenia
from derivatization of active molecule
Eur. J. Med. Chem., Jul. 5, 2020
Taisho Pharmaceutical, Saitama, JP
MGS0274
1 min read
MGS0274 is a prodrug of an mGlu2/3 receptor agonist with ca. 15x greater oral exposure than the parent. The ester is believed to be cleaved pre-systemically by liver carboxyesterases to release the innocuous byproducts acetaldehyde, CO2, and menthol. The parent is also an interesting looking molecule prepared in a few steps from cyclopentenone (ref. 9 in article).
Search By Structure
- A-1331852
- dotinurad (FYU-981)
- X-165
- “compound 38a”
- HTL22562
- “compound 23”
- MGS0274
- LXE408
- “compound 2”
- AB680
- “compound 18”
- ETX0282
- “compound 6g”
- EC2629
Molecules of the Month
2023
2022
2021
2020