Structure of compound 6g

potent and orally available SGLT1/2 dual inh.

activity in diabetes glucose tolerance model

based on natural product phlorizin

Bioorg. Med. Chem. Lett., Jul. 5, 2020

Janssen R&D, Spring House, PA.

“compound 6g” is an oral inhibitor of the sodium-glucose co-transporters (SGLTs) 1 and 2, intended for the treatment of hyperglycemia. SGLT2 selective inhibitors (gliflozins) are approved for treatment of type…

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