fbpx

molecules of the month

“compound 6g”

potent and orally available SGLT1/2 dual inh.

activity in diabetes glucose tolerance model

based on natural product phlorizin

Bioorg. Med. Chem. Lett., Jul. 5, 2020

Janssen R&D, Spring House, PA.

Structure of compound 6g
1 min read

“compound 6g” is an oral inhibitor of the sodium-glucose co-transporters (SGLTs) 1 and 2, intended for the treatment of hyperglycemia. SGLT2 selective inhibitors (gliflozins) are approved for treatment of type 2 diabetes, and an SGLT1/2 dual inhibitor is expected to result in greater glycemic control. Like other SGLT inhibitors, this molecule is based on a natural product scaffold, and the analogs don’t look super easy to make (I was surprised to see a BAST difluorination proceed in 74% yield on a highly substituted ketone prone to elimination).


request a trial

You don’t have time to read everything, but you can’t afford to fall behind.

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples.

Get ahead now by requesting a trial.


already a member? log in: