potent and orally available SGLT1/2 dual inh.
activity in diabetes glucose tolerance model
based on natural product phlorizin
Bioorg. Med. Chem. Lett., Jul. 5, 2020
Janssen R&D, Spring House, PA.
“compound 6g” is an oral inhibitor of the sodium-glucose co-transporters (SGLTs) 1 and 2, intended for the treatment of hyperglycemia. SGLT2 selective inhibitors (gliflozins) are approved for treatment of type…