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Structure of dotinurad, a novel selective urate reabsorption inhibitor

dotinurad (FYU-981)

Recent Publication

uric acid uptake (URAT1 transporter) inhibitor

approved as new uricosuric med. In JP

optimized to avoid mitochondrial toxicity

ACS Med. Chem. Lett., Jul. 20, 2020

Fuji Yakuhin, Saitama, JP

dotinurad (FYU-981) potently inhibits uric acid uptake by renal proximal tubule epithelial cells, increasing uric acid urinary secretion which can help hyperuricemic conditions like gout. The mechanism of action is…


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