QPX7728 is an ultrabroad-spectrum beta-lactamase inhibitor with activity against both serine and zinc metallo-beta-lactamases, in contrast to approved beta-lactamase inhibitors such as relebactam which are only active against serine metalloproteases. Interestingly, the boron of the molecule coordinates to serine hydroxyl groups in serine
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Sep. 17, 2021
QPX7728: an ultrabroad-spectrum beta-lactamase inhibitor
QPX7728
serine and metallo-beta-lactamase inhibitor oral activity in resistant infection model from optimization of literature starting point J. Med. Chem., Apr. 2, 2020 Qpex Biopharma, San Diego, CA