“Compound ( P )-14″ is a PI3K beta-isoform selective lipid kinase inhibitor. While the compound is potent and has excellent oral PK in higher species, significant irreversible toxicity was observed in a tox. study, and the chemical series was discontinued. It’s always great when organizations disclose tox. findings to educate the community [...]
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Sep. 17, 2021
Compound (P)-14: a PI3K beta-isoform selective lipid kinase inhibitor
“Compound (P)-14″
atropisomeric PI3K beta-selective inhibitor off-target tox. in higher species, discontinued from rational design of known starting point J. Med. Chem., Apr. 15, 2020 Gilead Sciences, Seattle, WA + Foster