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Sep. 17, 2021

S6821: A Potent and Selective TAS2R8 GPCR Antagonist


potent and selective TAS2R8 GPCR antagonist approved non-systemic bitter taste blocker from 200k cmpd cell-based screen and opt. J. Med. Chem., Apr. 24, 2020 Firmenich SA, San Diego, CA

Drug Hunter Team

S6821 is one of two potent and selective TAS2R8 GPCR antagonists disclosed by Firmenich, a fragrance and flavor company. These compounds block bitter taste receptors and don’t have significant systemic exposure, and have been approved as safe for use. I thought it was interesting to see high-quality medicinal chemistry applied in a [...]



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