potent and selective TAS2R8 GPCR antagonist
approved non-systemic bitter taste blocker
from 200k cmpd cell-based screen and opt.
J. Med. Chem., Apr. 24, 2020
Firmenich SA, San Diego, CA
S6821
1 min read
S6821 is one of two potent and selective TAS2R8 GPCR antagonists disclosed by Firmenich, a fragrance and flavor company. These compounds block bitter taste receptors and don’t have significant systemic exposure, and have been approved as safe for use. I thought it was interesting to see high-quality medicinal chemistry applied in a non-traditional setting.
Search By Structure
- tucatinib
- S6821
- MRTX849
- BAY1161909
- ORN0829
- BMS-986251
- GSK2818713
- CPI-1612
- “Compound 19”
- AZD4205
- QPX7728
- “Compound 9”
- “Compound (P)-14″
- FT385
Molecules of the Month
2023
2022
2021
2020