molecules of the month


potent and selective TAS2R8 GPCR antagonist

approved non-systemic bitter taste blocker

from 200k cmpd cell-based screen and opt.

J. Med. Chem., Apr. 24, 2020

Firmenich SA, San Diego, CA

1 min read

S6821 is one of two potent and selective TAS2R8 GPCR antagonists disclosed by Firmenich, a fragrance and flavor company. These compounds block bitter taste receptors and don’t have significant systemic exposure, and have been approved as safe for use. I thought it was interesting to see high-quality medicinal chemistry applied in a non-traditional setting.

request a trial

You don’t have time to read everything, but you can’t afford to fall behind.

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples.

Get ahead now by requesting a trial.

already a member? log in: