S6821 is one of two potent and selective TAS2R8 GPCR antagonists disclosed by Firmenich, a fragrance and flavor company. These compounds block bitter taste receptors and don’t have significant systemic exposure, and have been approved as safe for use. I thought it was interesting to see high-quality medicinal chemistry applied in a [...]
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Sep. 17, 2021
S6821: A Potent and Selective TAS2R8 GPCR Antagonist
S6821
potent and selective TAS2R8 GPCR antagonist approved non-systemic bitter taste blocker from 200k cmpd cell-based screen and opt. J. Med. Chem., Apr. 24, 2020 Firmenich SA, San Diego, CA