potent and selective TAS2R8 GPCR antagonist
approved non-systemic bitter taste blocker
from 200k cmpd cell-based screen and opt.
J. Med. Chem., Apr. 24, 2020
Firmenich SA, San Diego, CA
S6821 is one of two potent and selective TAS2R8 GPCR antagonists disclosed by Firmenich, a fragrance and flavor company. These compounds block bitter taste receptors and don’t have significant systemic…