molecules of the month


broad geno. HCV NS5A repl. complex inhibitor

low Cl and orally available in higher species

from rational design from known ligand

J. Med. Chem., Apr. 23, 2020

GlaxoSmithKline, Research Triange Park, NC

1 min read

GSK2818713 is an HCV NS5A replication complex inhibitor with an interesting biphenylene linker. The crowded, hotly competitive NS5A space has led to a lot of creative chemical scaffolds including this one.

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