FT385

USP30-sel. covalent DUB enzyme inhibitor

active in cells and selective vs. DUB panel

undisclosed, related to lit. DUB inhibitors

BioRXiV, Apr. 20, 2020

FORMA Therapeutics / U. Liverpool

FT385 is a covalent inhibitor of the USP30 deubiquitinating enzyme with a cyanopyrrolidine warhead. Identifying selective active-site inhibitors of de-ubiquitinating enzymes has been challenging, and FT385 now provides a good…


 become a member to continue reading

Ask your company or librarian about a Drug Hunter membership to to see all summaries and get access to even more helpful information.

  • Stay up-to-date and save more time with exclusive members-only content
  • On-board new team members with educational content and case studies
  • Generate ideas and discussion with easy-to-read slide decks
  • Generate ideas and discussion with easy-to-read slide decks