< 1 minute read
Sep. 17, 2021

FT385: a Covalent Inhibitor of The USP30 Deubiquitinating Enzyme


USP30-sel. covalent DUB enzyme inhibitor active in cells and selective vs. DUB panel undisclosed, related to lit. DUB inhibitors BioRXiV, Apr. 20, 2020 FORMA Therapeutics / U. Liverpool

Drug Hunter Team

FT385 is a covalent inhibitor of the USP30 deubiquitinating enzyme with a cyanopyrrolidine warhead. Identifying selective active-site inhibitors of de-ubiquitinating enzymes has been challenging, and FT385 now provides a good tool compound to study USP30 biology. Some of my colleagues at Genentech recently published on the mechanism of [...]



Other molecules you may be interested in