bioavailable EP300/CBP HAT inhibitor
brain penetrant, orally efficacious in xeno.
from HTS and SBDD
ACS Med. Chem. Lett., Apr. 27, 2020
Constellation Pharma., Cambridge, MA
CPI-1612 is a pretty efficient-looking EP300/CBP histone acetyltransferase (HAT) inhibitor tool compound with demonstrated activity in a xenograft model and good higher species PK. While epigenetics targets like HATs have…