M3-selective positive allosteric modulator
oral bioavailability in rodent
from HTS and optimization
Bioorg. Med. Chem. Apr. 23, 2020
Astellas Pharma, Tsukuba, JP
“Compound 9”
“Compound 9” is the first potent M3-selective positive allosteric modulator, with potential utility as a biological tool compound. It does have secondary activity against M5 at high doses though. It’s…