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Sep. 17, 2021

QPX7728: an ultrabroad-spectrum beta-lactamase inhibitor


serine and metallo-beta-lactamase inhibitor oral activity in resistant infection model from optimization of literature starting point J. Med. Chem., Apr. 2, 2020 Qpex Biopharma, San Diego, CA

Drug Hunter Team

QPX7728 is an ultrabroad-spectrum beta-lactamase inhibitor with activity against both serine and zinc metallo-beta-lactamases, in contrast to approved beta-lactamase inhibitors such as relebactam which are only active against serine metalloproteases. Interestingly, the boron of the molecule coordinates to serine hydroxyl groups in serine



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