molecules of the month


serine and metallo-beta-lactamase inhibitor

oral activity in resistant infection model

from optimization of literature starting point

J. Med. Chem., Apr. 2, 2020

Qpex Biopharma, San Diego, CA

1 min read

QPX7728 is an ultrabroad-spectrum beta-lactamase inhibitor with activity against both serine and zinc metallo-beta-lactamases, in contrast to approved beta-lactamase inhibitors such as relebactam which are only active against serine metalloproteases. Interestingly, the boron of the molecule coordinates to serine hydroxyl groups in serine beta-lactamases, whereas it coordinates as a boronate ligand to the zinc centers of metallo-beta-lactamases.

request a trial

You don’t have time to read everything, but you can’t afford to fall behind.

Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples.

Get ahead now by requesting a trial.

already a member? log in: