oral DHODH inhibitor

tumor growth inhibition in xenograft models

from virtual screening and SBDD

J. Med. Chem.

Janssen, Spring House, PA

compound 19 chemical structure oral DHODH inhibitor - Janssen, Spring House, PA

Context. “Compound 19” (Janssen) is an oral dihydroorotate dehydrogenase (DHODH) inhibitor being developed for acute myelogenous leukemia (AML). DHODH is a ubiquitously expressed, essential enzyme in the de novo…

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