oral DHODH inhibitor
tumor growth inhibition in xenograft models
from virtual screening and SBDD
J. Med. Chem.
Janssen, Spring House, PA
Context. “Compound 19” (Janssen) is an oral dihydroorotate dehydrogenase (DHODH) inhibitor being developed for acute myelogenous leukemia (AML). DHODH is a ubiquitously expressed, essential enzyme in the de novo…