oral CAT K inhibitior

reduced uCTX-I levels in dog model

from opt of a previously disclosed cmpd

Bioorg. Med. Chem. Lett.

Merck, West Point, PA

compound 23 chemical structure oral CAT K inhibitior - Merck, West Point, PA

Context. “Compound 23” (Merck) is a selective oral cathepsin K (CatK) inhibitor intended for osteoarthritis.  Osteoarthritis affects around 15% of the population, and current treatments offer only symptom relief,…

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