After evaluating thousands of articles and hundreds of candidates, a brain-penetrant pre-mRNA splicing modulator, a gut-restricted candidate for Parkinson’s disease (you read that correctly), and a male contraceptive mechanism are among this highlights of this edition of Molecules of the Month.  Learn more about the molecules by navigating to the full reviews on the right which cover: why the molecules matter, how they were discovered, the key steps behind optimization, how the drugs work, why the targets were chosen, interesting toxicology and clinical data, and more. Sign up for our free weekly newsletter here to get more content like this straight to your inbox. Not a member? Get a free trial to check out substructure search and more features.