oral SMARCA2/4 and PBRM1 selective inhibitor

oral PK observed in mouse

from 43k cmps HTS and SBDD

J. Med. Chem.

Genentech, South San Francisco, CA

GNE-064 chemical structure oral SMARCA2/4 and PBRM1 selective inhibitor - Genentech, South San Francisco, CA

Context. GNE-064 (Genentech) is an oral inhibitor of the bromodomains of SMARCA2/4 and PBRM1 being developed as a tool compound. Many proteins contain bromodomains (there are 61 in the…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: