oral SMARCA2/4 and PBRM1 selective inhibitor
oral PK observed in mouse
from 43k cmps HTS and SBDD
J. Med. Chem.
Genentech, South San Francisco, CA
Context. GNE-064 (Genentech) is an oral inhibitor of the bromodomains of SMARCA2/4 and PBRM1 being developed as a tool compound. Many proteins contain bromodomains (there are 61 in the…