5 minute read
Sep. 28, 2022

AZD4831: an Oral Covalent Myeloperoxidase (MPO) Inhibitor for Heart Failure

AZD4831

oral MPO covalent inhibitor Ph. IIb/III candidate in HFpEF previous literature and selectivity opt J. Med. Chem. AstraZeneca, Gothenburg, SE

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Drug Hunter Team

AZD4831 (AstraZeneca) is an oral covalent myeloperoxidase (MPO) inhibitor being developed for heart failure. Almost half of chronic heart disease patients suffer from heart failure with a preserved ejection fraction (HFpEF) and have an estimated five-year mortality rate of 75% . Improvement in vascular structure could help these [...]

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