YAP-TEAD PPI inhibitor

single digit nanomolar potency

virtual screening and SBDD

ChemMedChem

Novartis, Basel, Switzerland

compound 6 chemical structure YAP-TEAD PPI inhibitor - Novartis, Basel, Switzerland

Context. “Compound 6” (Novartis) is a first-in-class YAP-TEAD protein-protein inhibitor. The TEAD transcription factor and its coactivator YAP and WWTR1/TAZ of the Hippo pathway are responsible for directly regulating…


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