oral 20S proteasome inhibitor

efficacy in stage II mouse model of HAT

3 million cmpd HTS and SBDD

J. Med. Chem.

Novartis Institutes for Biomedical Research, Emeryville, CA

compound 7 chemical structure oral 20S proteasome inhibitor - Novartis Institutes for Biomedical Research, Emeryville, CA

Context. “Compound 7” (NIBR) is an oral Trypanosoma brucei 20S proteasome inhibitor being developed for Human African Trypanosomiasis (HAT). African sleeping sickness, or HAT, is caused by a parasite…


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