The January 2022 edition of Drug Hunter’s Small Molecules of the Month includes a reversible CoV-2 main protease inhibitor from Shionogi in Ph. II/III which doesn’t require a PK booster like ritonavir, a recently disclosed oral, once-daily Factor XIa inhibitor, and the first-in-class STING agonist that was once Aduro’s lead.

Thanks to reviewers for their feedback this month.

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