This month's edition of Drug Hunter's Molecules of the Month include Principia's reversible covalent BTK inhibitors and a single-dose antimalarial. Thanks to Bryan McKibben, Dennis Koester, Callie Bryan, and Christian Kuttruff for their nominations this month. To access our deep dives into the context, clinical development, mechanisms of action, hit-finding strategies, lead optimization, preclinical pharmacology, and more information and insights you won't find in the papers, subscribe to Premium.