Chemical structure of FRM-024

oral gamma secretase modulator

preclinical PD at 30 mpk single dose

from opt. of prior oxadiazine GSM

Journal of Medicinal Chemistry

FORUM Pharmaceuticals

The FORUM Pharmaceuticals CNS-penetrant gamma secretase inhibitor and preclinical candidate, FRM-024, is an advanced example of the use of an oxadiazine as an amide isostere. While amide isosteres are frequently proposed,…


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