The December edition of Small Molecules of the Month includes a Ph. III candidate identified from machine-learning-assisted in vivo phenotypic screening, Mirati’s KRAS G12D inhibitor, and several kinase inhibitors outside of oncology. Thanks to reviewers Joachim Rudolph, Naomi Rajapaksa, Julien Lefranc, Christian Kuttruff, Christian Gampe, Jake Schwarz, Yoana Dimitrova, Anthony Vaganos, and Kim Huard for their nominations and key insights this month. Premium subscribers can read details behind each molecule and download the slide deck. Sign up for the free e-mail newsletter to get a preview each month.