oral gamma secretase modulator
preclinical PD at 30 mpk single dose
from opt. of prior oxadiazine GSM
Journal of Medicinal Chemistry
FORUM Pharmaceuticals
FRM-024
The FORUM Pharmaceuticals CNS-penetrant gamma secretase inhibitor and preclinical candidate, FRM-024, is an advanced example of the use of an oxadiazine as an amide isostere. While amide isosteres are frequently proposed,…