The FORUM Pharmaceuticals CNS-penetrant gamma secretase inhibitor and preclinical candidate, FRM-024 , is an advanced example of the use of an oxadiazine as an amide isostere . While amide isosteres are frequently proposed, it is often difficult to implement them beyond basic heterocyclic replacements. A benzofuran structural alert was [...]
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Nov. 26, 2021
FRM-024: A CNS-Penetrant γ-Secretase Inhibitor
FRM-024
oral gamma secretase modulator preclinical PD at 30 mpk single dose from opt. of prior oxadiazine GSM Journal of Medicinal Chemistry FORUM Pharmaceuticals