Chemical structure of FRM-024

oral gamma secretase modulator

preclinical PD at 30 mpk single dose

from opt. of prior oxadiazine GSM

Journal of Medicinal Chemistry

FORUM Pharmaceuticals

The FORUM Pharmaceuticals CNS-penetrant gamma secretase inhibitor and preclinical candidate, FRM-024, is an advanced example of the use of an oxadiazine as an amide isostere. While amide isosteres are frequently proposed,…

 this content is exclusive to
Premium members

Unlock this content with a Premium membership to read it now.