© Rosalind Scientific LLC 2018-2022
© Rosalind Scientific LLC, 2018-2022
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oral gamma secretase modulator
preclinical PD at 30 mpk single dose
from opt. of prior oxadiazine GSM
Journal of Medicinal Chemistry
The FORUM Pharmaceuticals CNS-penetrant gamma secretase inhibitor and preclinical candidate, FRM-024, is an advanced example of the use of an oxadiazine as an amide isostere. While amide isosteres are frequently proposed,…
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