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Nov. 26, 2021

FRM-024: A CNS-Penetrant γ-Secretase Inhibitor


oral gamma secretase modulator preclinical PD at 30 mpk single dose from opt. of prior oxadiazine GSM Journal of Medicinal Chemistry FORUM Pharmaceuticals

Drug Hunter Team

The FORUM Pharmaceuticals CNS-penetrant gamma secretase inhibitor and preclinical candidate, FRM-024 , is an advanced example of the use of an oxadiazine as an amide isostere . While amide isosteres are frequently proposed, it is often difficult to implement them beyond basic heterocyclic replacements. A benzofuran structural alert was [...]



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