oral gamma secretase modulator

preclinical PD at 30 mpk single dose

from opt. of prior oxadiazine GSM

Journal of Medicinal Chemistry

FORUM Pharmaceuticals

Chemical structure of FRM-024

The FORUM Pharmaceuticals CNS-penetrant gamma secretase inhibitor and preclinical candidate, FRM-024, is an advanced example of the use of an oxadiazine as an amide isostere. While amide isosteres are frequently proposed,…

get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: