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Nov. 26, 2021

Sivopixant: A P2X3 ligand-gated Ion Channel Antagonist


purinergic receptor (ion channel) antagonist up to 300 mg PO QD, phase IIb, chronic cough from opt. of prior P2X3 antagonist Bioorganic and Medicinal Chemistry Letters Shionogi

Drug Hunter Team

The Shionogi P2X3 ligand-gated ion channel antagonist, sivopixant ( S-600918 ), is an oral Ph. II candidate for refractory chronic cough, which recently completed a its Ph. IIb study, overcoming the projected high dose requirement of a prior preclinical candidate. The molecule has a very polar core structure with both a dioxotriazine and [...]



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