Chemical structure of molecule S-600918

purinergic receptor (ion channel) antagonist

up to 300 mg PO QD, phase IIb, chronic cough

from opt. of prior P2X3 antagonist

Bioorganic and Medicinal Chemistry Letters


The Shionogi P2X3 ligand-gated ion channel antagonist, sivopixant (S-600918), is an oral Ph. II candidate for refractory chronic cough, which recently completed a its Ph. IIb study, overcoming the projected high…

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