purinergic receptor (ion channel) antagonist

up to 300 mg PO QD, phase IIb, chronic cough

from opt. of prior P2X3 antagonist

Bioorganic and Medicinal Chemistry Letters


Chemical structure of molecule S-600918

The Shionogi P2X3 ligand-gated ion channel antagonist, sivopixant (S-600918), is an oral Ph. II candidate for refractory chronic cough, which recently completed a its Ph. IIb study, overcoming the projected high…

get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: