penicillin-binding protein + _-lactamase inh.
preclin. eff. at 50 mpk SC, 2,000 mpk tolerated
multitarget SBDD + opt. for porin permeability
The Entasis broad-spectrum antibiotic, ETX0462, is both an inhibitor of penicillin-binding proteins (PBPs, the target of beta-lactams) and a beta-lactamase inhibitor (BLI). Reviewer Mike Koehler thought this was a substantial disclosure. “A…