2 minute read
Nov. 26, 2021

ETX0462: A Broad-Spectrum Beta-Lactamase Inhibitor with Single-Agent Activity


penicillin-binding protein + β-lactamase inh. preclin. eff. at 50 mpk SC, 2,000 mpk tolerated multitarget SBDD + opt. for porin permeability Nature Entasis Therapeutics

Drug Hunter Team

The Entasis broad-spectrum antibiotic, ETX0462 , is both an inhibitor of penicillin-binding proteins (PBPs, the target of beta-lactams) and a beta-lactamase inhibitor (BLI). Reviewer Mike Koehler thought this was a substantial disclosure. “A number of BLIs co-formulated with carbapenems and monobactams are currently on the market. There are a [...]



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