penicillin-binding protein + _-lactamase inh.

preclin. eff. at 50 mpk SC, 2,000 mpk tolerated

multitarget SBDD + opt. for porin permeability

Nature

Entasis Therapeutics

Chemical structure of molecule ETX0462

The Entasis broad-spectrum antibiotic, ETX0462, is both an inhibitor of penicillin-binding proteins (PBPs, the target of beta-lactams) and a beta-lactamase inhibitor (BLI). Reviewer Mike Koehler thought this was a substantial disclosure. “A…


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