G-protein biased GPCR agonist

oral 10 mg QD, phase I, cardiovascular

from HTS and opt.



Chemical structure of SAR247799

The Sanofi S1P1 agonist,┬áSAR247799, is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G-protein signaling over the ╬▓-arrestin and internalization pathways. Commercial S1P1 modulators such as fingolimod…

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