G-protein biased GPCR agonist

oral 10 mg QD, phase I, cardiovascular

from HTS and opt.

bioRxiv

Sanofi

Chemical structure of SAR247799

The Sanofi S1P1 agonist,┬áSAR247799, is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G-protein signaling over the ╬▓-arrestin and internalization pathways. Commercial S1P1 modulators such as fingolimod…


get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: