oral CRBN-based androgen receptor degrader
preclinical eff. at 10 mpk QD (xenograft)
from previously disclosed AR molecule
Journal of Medicinal Chemistry
University of Michigan
ARD-2585
The Michigan bifunctional degrader, ARD-2585, is similar to the Arvinas molecule, ARV-110 that was recently disclosed at AACR 2021. ARV-110 is a first-in-class, potent, and orally active AR degrader in…