oral CRBN-based androgen receptor degrader

preclinical eff. at 10 mpk QD (xenograft)

from previously disclosed AR molecule

Journal of Medicinal Chemistry

University of Michigan

Chemical structure of ARD-2585

The Michigan bifunctional degrader, ARD-2585, is similar to the Arvinas molecule, ARV-110 that was recently disclosed at AACR 2021. ARV-110 is a first-in-class, potent, and orally active AR degrader in…


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