oral ROR_ nuclear receptor agonist

450 mg BID, phase I/II, cancer

from change in MoA of ROR_ antagonist + opt.

Journal of Medicinal Chemistry

Lycera

The Lycera ROR gamma agonist, cintirorgon (LYC-55716), is a first-in-class phase 1b clinical candidate for cancer immunotherapy (in combination with pembrolizumab in NSCLC). ROR gamma antagonists have been extensively…


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