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Nov. 26, 2021

JNJ-67569762: A BACE1-Selective Inhibitor


oral BACE1-selective inhibitor preclinical, QTc observed in dogs from literature starting point Journal of Medicinal Chemistry Janssen Pharmaceutica NV

Drug Hunter Team

The Janssen BACE1-selective inhibitor, JNJ-67569762 , was a preclinical candidate for Alzheimer’s disease. Obtaining BACE1 over BACE2 selectivity was a major challenge in the field, and the molecule is 74x selective thanks to a bicyclic ring system in the S3 pocket. In in vivo models, BACE1-mediated PD was observed without BACE2-dependent [...]



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