potent and selective Mcl-1 PPI inhibitor

completed Ph. I in AML/MDS (IV weekly)

from NMR fragment screening and SBDD

J. Med. Chem., Nov. 4, 2020

Servier, HU + FR / Vernalis, UK

Structure of S64315, a potent and selective Mcl-1 inhibitor

Servier selective clinical Mcl-1 protein-protein interaction (PPI) inhibitor

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