oral G2019S-LRRK2 mut.-selective kinase inh.

>70x sel. for ParkinsonÕs mut. over WT, non-BP

from 50k cmpd HTS + homology-based opt.

J. Med. Chem., Nov. 16, 2020

ESCAPE Bio, South San Francisco, CA

Structure of EB-42486 - a potent, oral inhibitor of leucine-rich repeat kinase 2 (LRRK2)

EB-42486 (ESCAPE Bio oral G2019S-LRRK2 mutant-selective kinase inhibitor)

get free samples and a Premium trial

Premium members get access to our library of hundreds of in-depth reviews on key molecules, ten new reviews each month, novel drug approval coverage, drug discovery company updates, and more: