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molecules of the month

“peptide 78”

potent macrocyclic PCSK9 PPI inhibitor

1000x optimization of biochem. activity

from mRNA display screen and SBDD

J. Med. Chem., 2020, Nov. 10, 2020

Merck, PA + NJ / UCB Ra Pharma, MA

Structure of potent macrocyclic PCSK9 PPI inhibitor peptide-78
1 min read

Merck/UCB/Ra Pharma macrocyclic PCSK9 protein-protein interaction (PPI) inhibitor


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