potent macrocyclic PCSK9 PPI inhibitor
1000x optimization of biochem. activity
from mRNA display screen and SBDD
J. Med. Chem., 2020, Nov. 10, 2020
Merck, PA + NJ / UCB Ra Pharma, MA
“peptide 78”
1 min read
Merck/UCB/Ra Pharma macrocyclic PCSK9 protein-protein interaction (PPI) inhibitor
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- LY3502970
- S64315
- daridorexant
- “peptide 78”
- BMS-986144
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- “compound 60b”
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