Structure of compound 15a

reversible ATX inhibitor w/ alt. binding mode

in vivo PD observed on oral dosing

from HTS screen and opt.

Bioorg. Med. Chem. Lett., Nov. 4, 2020

Novartis, Horsham, UK / Basel, CH

“compound 15a” (Novartis reversible in vivo ATX inhibitor)

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