molecules of the month

“compound 4j”

5-HT2 antagonist and 5-HT7 inverse agonist

brain penetrant, oral efficacy in rodent models

backup candidate to JNJ-18038683

Bioorg. Med. Chem. Lett., Nov. 7, 2020

Janssen, San Diego, CA

Structure of compound 4j
1 min read

“compound 4j” (Janssen (JNJ) brain-penetrant in vivo 5-HT2 antagonist and 5-HT7 inverse agonist, backup candidate)

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