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Structure of potent macrocyclic PCSK9 PPI inhibitor peptide-78

“peptide 78”

Recent Publication

potent macrocyclic PCSK9 PPI inhibitor

1000x optimization of biochem. activity

from mRNA display screen and SBDD

J. Med. Chem., 2020, Nov. 10, 2020

Merck, PA + NJ / UCB Ra Pharma, MA

Merck/UCB/Ra Pharma macrocyclic PCSK9 protein-protein interaction (PPI) inhibitor

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