covalent allosteric OTUB1-recruiting DUBTAC

induced deubiq./stabilization of _F508-CFTR

from gel-based screen of 702 covalent ligands

bioRxiv, Apr. 30, 2021

UC Berkeley / Novartis (NIBR)

The UC Berkeley and Novartis deubiquitinating enzyme-recruiting chimera (DUBTAC), NJH-2-057, has a warhead that covalently targets a non-catalytic allosteric cysteine on the deubiquitinase (DUB) OTUB1. The CFTR-binding moiety recruits OTUB1…

 this content is exclusive to
Premium members

Unlock this content with a Premium membership to read it now.