covalent allosteric OTUB1-recruiting DUBTAC

induced deubiq./stabilization of _F508-CFTR

from gel-based screen of 702 covalent ligands

bioRxiv, Apr. 30, 2021

UC Berkeley / Novartis (NIBR)

NJH-2-057

The UC Berkeley and Novartis deubiquitinating enzyme-recruiting chimera (DUBTAC), NJH-2-057, has a warhead that covalently targets a non-catalytic allosteric cysteine on the deubiquitinase (DUB) OTUB1. The CFTR-binding moiety recruits OTUB1…


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