oral pan-RAF Type II kinase inhibitor tool

combo. efficacy in KRAS+ models w/ MEKi

SBDD from literature ligands

ACS Med. Chem. Lett., Apr. 21, 2021

Genentech, South San Francisco, CA


The Genentech pan-RAF Type II kinase inhibitor, GNE-9815, is an oral chemical probe and among the most highly kinase-selective inhibitors of RAF reported. Interestingly, it minimally engages the hinge region of the…

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