oral pan-RAF Type II kinase inhibitor tool
combo. efficacy in KRAS+ models w/ MEKi
SBDD from literature ligands
ACS Med. Chem. Lett., Apr. 21, 2021
Genentech, South San Francisco, CA
GNE-9815
The Genentech pan-RAF Type II kinase inhibitor, GNE-9815, is an oral chemical probe and among the most highly kinase-selective inhibitors of RAF reported. Interestingly, it minimally engages the hinge region of the…