topical (skin-restricted) ROR_ antagonist
efficacy in psoriasis model / minipig PK
from GSK-805 and met. stability reduction
Sci. Rep., Apr. 28, 2021
Eternity Bioscience, NJ / Shanghai Hengrui, CN
SHR168442
The Eternity Bioscience/Shanghai Hengrui RORĪ³ antagonist, SHR168442, is a skin-restricted, topical compound intended to treat psoriasis. As a master regulator of Th17 immune cells which are significantly involved in allergic diseases,…