topical (skin-restricted) ROR_ antagonist

efficacy in psoriasis model / minipig PK

from GSK-805 and met. stability reduction

Sci. Rep., Apr. 28, 2021

Eternity Bioscience, NJ / Shanghai Hengrui, CN

The Eternity Bioscience/Shanghai Hengrui RORĪ³ antagonist, SHR168442, is a skin-restricted, topical compound intended to treat psoriasis. As a master regulator of Th17 immune cells which are significantly involved in allergic diseases,…

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